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Think about it: Heart disease and diabetes, which account for more deaths in the U.S. and worldwide than everything else combined, are completely preventable by making comprehensive lifestyle changes. Without drugs or surgery.

We all know we're going to die one day, but who wants to think about it? What's sustainable is joy, pleasure and freedom.

Because the biological mechanisms that affect our health and well-being are so dynamic, when people change their diet and lifestyle, they usually feel so much better, so quickly; it reframes the reason for changing from fear of dying to joy of living. Also, the support that patients give each other is a powerful motivator.

People who are lonely and depressed are three to 10 times more likely to get sick and die prematurely than those who have a strong sense of love and community. I don't know any other single factor that affects our health - for better and for worse - to such a strong degree.

When most people think about my work, they think about diet. To me, diet has always been the least interesting part of it.

There's no point in giving up something you enjoy unless you get something back that's even better, and quickly.

Joy of living is sustainable; fear of dying is not.

What matters most is your overall way of eating and living.

I've found that if I tell somebody 'Eat this and don't do that,' it's not only not helpful, it's counterproductive because even more than being healthy, we want to feel free and in control, and as soon as somebody tells us to do something, there's a tendency to do just the opposite.

Even more than feeling healthy, most people want to feel free and in control.

Whether you're six or sixty, if you go on a diet and lifestyle program and feel constrained, you're likely to go off it sooner or later. Offering a spectrum of choices is much more effective; then, you feel free and empowered.

If I eat mindlessly while watching television, reading, or talking with someone else, I can go through an entire meal without tasting the food, without even noticing that I've been eating. The plate is empty but I didn't enjoy the food - I had all of the calories and little of the pleasure.

I grew up in Texas, eating meat five times a day, and I liked meat. But I began being a vegetarian when I was 19 because I found that I felt better.

The reason I spend so much of my time doing science is that the whole point of science is to help people resolve conflicting claims by saying: 'Show me the data.'

I'm a big admirer of Walter Willett's work. I think he's done some really important research. He and I agree on most things.

I never give up hope.

The need for connection and community is primal, as fundamental as the need for air, water, and food.

While the digital age has done so much to improve our world, it has dramatically changed our social structure, often further isolating us from each other.

With everything that you can imagine at our fingertips, many of the social interactions that help tie people together in a community have faded away. Are communities traditionally built on relationships, trust and familiarity a thing of the past?

The need for love and intimacy is a fundamental human need, as primal as the need for food, water, and air.

When you grow up in an extended family, or in a stable neighborhood with two or three generations of families who live there, you feel seen. Not just the good things you've done, the stuff you put on your resume. You know they've seen you in your dark times, when you've messed up - but they're still there.

Science is simply a powerful way of understanding what's real and what isn't, what's true and what's not. It can help us determine what works, what doesn't, for whom, and under what circumstances.

A valid scientific theory is predictive, verifiable, and replicable. To me, that's beautiful.

Although scientists can often be as resistant to new ideas as anyone, the process of science ensures that, over time, good ideas and theories prevail.

The Internet has transformed many parts of our daily lives, touching everything from how we find information to how we go shopping, get directions, and even stay in touch with friends and family.

Whether it's by helping us search for health-related information, connecting us with doctors through online portals, or enabling us to store and retrieve our medical records online, the Internet is starting to show the promise it has to transform the way people interact with and improve their own health and wellness.

Curious patients are more receptive to new ideas, and those who engage their health practitioners in a dialogue are much more likely to adhere to these recommendations.

An educated patient is empowered; thus, more likely to become healthy.

In general, losing weight is a good thing for those who are overweight, but it's important to lose weight in a way that enhances your health rather than one that may compromise it.

I am as non-accepting of medical quackery and unscientific approaches as anybody else. I've grown up as a card-carrying scientist, and I know the power of science to answer questions, and for many questions I don't know of anything better than scientific approaches to answer them.

Knowledge and engagement are a powerful antidote to forces that often work against our kids being healthy.

I appreciate the power of a White House bully pulpit - but kids listen and learn primarily from other kids. If your son's friend tells him that the apple is better than the fries, he's more likely to listen.

Parents and kids know they should pass up the fries for an apple and exchange the video game for a game of tag - but knowing and doing are certainly different things.

Educators and school personnel work on the front lines of childhood obesity, but every day they face the challenges of budget cuts, mandated tests, rushed lunch periods, and a decrease in time for physical activity.

No one has a monopoly on truth, and science continues to advance. Yesterday's heresies may be tomorrow's conventional wisdom.

A little humility goes a long way.

Just like navigating in the open sea, triangulating the information you collect from media with your doctor's advice and some common sense will help map a sound path to safety.

Let's all be more humble about the evidence behind medical advice but also respect the challenges to providing accessible lifestyle guidance.

No one has all the answers, so whatever a woman who has the BRCA mutation chooses to do requires courage and an element of faith. And a lot of love and support.

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