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For healthy adult people, the really big thing we can foresee are ways of intervening in the ageing process, either by slowing or reversing it.
I can't imagine having a conversation about 'Celebrity Big Brother' in Cambridge, Massachusetts.
Americans are big boys. You can talk them into almost anything. Just sit with them for half an hour over a bottle of whiskey and be a nice guy.
I'm channelling my 14-year-old self. She's thinking about putting on her big hoop earrings and baggy pants and going to the mall downtown.
My idea of horses is from when I grew up on a farm. They were big, and they were dumb.
At one time musical theater, particularly in the '40s and '50s, was a big source of pop songs. That's how musical theater started, really - it was just a way of linking several pop songs for the stage.
She's been a smack addict, she's had big success in Europe in the '70s, and she's lost everything. She's been rediscovered in the '80s, and as we meet her she's just about to sign a new recording contract.
I think we've come a long way since then. The big thing that changed was when ecstasy came along in Britain.
A lot of parts of L.A. are interchangeable with suburbs in Joburg. Very big, ostentatious houses with palm trees and lawns. Lawns are very important. Never underestimate lawns.
I'm not a big Woody Allen fan, but thought 'Husbands and Wives' was great.
I love Buster Keaton. I was a big fan of the stunt shows at Universal Studios. I'm a huge Cirque du Soleil nut.
I tend to be on the quiet side. I think I would have been bigger if I had a big mouth.
In fact, Moon came on tour with us for a bit just before a big festival in Brighton, I think.
People have made me so big now, which I never thought I can be as a female singer.
Why the hell do we make such a big deal out of things that shouldn't be a big deal?
My dad was a big believer in treating people well, oftentimes even when he himself wasn't well.
We forget the little things, so it's no wonder some of us screw up the big things.
What I went through in personal life had a big impression on my professional choices.
My favourite place to write is at my desk in my house in the mountains of Crete. I produce more there because one big distraction is missing: the Internet.
A big blockbuster like 'Kick' expands the audience for my films and makes it easier to promote them.
I find it's really hard for anybody to meet anyone. I'm not big on dates anyways. I still have to work that out.
It used to be that comic strips were the big thing, and comic books were toilet paper.
I really like dancehall. I really like reggae. I'm a big fan. Bob Marley and all that.
We knew we had to think global and think big. Most companies that are emerging don't do that.
These big jumps take a big toll on the body, especially a young body. So, it's kind of risk or reward, I guess.
Ever since I was a younger skater, I've been working my way to these big jumps.
My dad was a big runner. Growing up, I watched him do half marathons, and he was always running six or seven miles.
I started with theater when I was 9 years old and then got into television when I was 16, but I would say my first big break was 'Lady, La Vendedora de Rosas', a telenovela that was very successful all across Latin America.
When I was little, I wasn't so little. I had a big old round belly and I was really clumsy, but I was super confident.
Big Linux deployments have reached the point where it's become a real problem for administrators that they don't have nice tools to manage their servers and desktops.
I take jobs with people I admire, people with incredible talent who aren't necessarily big sellers.
I am a big believer that eventually everything comes back to you. You get back what you give out.
I said from the very beginning, I don't want a big house, I don't want big grounds, I don't want the trouble with the maintenance and all of that.
Going back to my own past as a reader, I was a big, big reader of romances, particularly as a teenager, the age that my books are aimed at.
I grew up in a courtroom kind of like the one you saw in 'To Kill a Mockingbird' - big, big courtroom, sometimes it didn't even have air conditioning.
I'm not going to tell the Palestinians how to arrange themselves. If they want to have their own entity and their own parliament as they do today, that's fine. If they want to connect to Jordan, which has a very big Palestinian population, and vote in the Jordanian government, that's fine.
Israel, contrary to most of the West, has a high fertility rate, so there's a lot of young people in Israel. Most families have three kids as opposed to one or two, so a big proportion of the population is under 30.
Haredi youth are smart, and they are going to bring a big benefit to the high-tech industry.
We are passing through a very sensitive time, and on the whole, this country is facing very big problems.
If a big number of young pupils felt secularism was an attack on them, it was because the term had been misused and deformed in the public debate for years by the extreme-right and the right as an attack on Islam. The term had often been misused to point out how Muslims were different to others, and that is clearly problematic.
Anything to do with any new form of tax, like consumption tax in Japan, carbon tax in Australia, these are big issues that cannot be easily decided.
When you show people on the big screen that could be our next-door neighbour or our cousin, it does have an impact on our lives.
Very obviously, the electorate as a mass has not imbibed the philosophy of 'think national, act local' or even 'think big and beyond' - it is a case, more, of 'think local, act local, and let the national equation take care of itself.'
I'm a really big fan of Andy McKee - I think he's an amazing acoustic guitar player, and he's taken the torch from where Michael Hedges left off.
If I hear about a big match coming up, I'll get anxiety about it, and I'll start thinking about it, like, 'What's gonna happen? Is this my shot?'
I made my debut on big screen, and many thanks to my mentor T. Rajendhar for introducing me to films.
When the Americans advance, we harass and retreat, fire from new positions and then retreat again. If the attacking force is too big, we call for support.
I'd say a big transition as a kid was when I started to listen to Good Charlotte. They were like a rap-to-rock/punk group.
I always wanted children but I was scared. Being responsible for a baby is such a big thing so I was nervous!
I listened to Pablo Casals, which was a big change for me. Without hearing Casals, I would never have advanced as I did.
Turing was fearless. He's extremely direct, which can be seen as socially awkward, and that becomes both his big obstacle but also, in many ways, his strength.
I lost agents and managers because I turned down big movies that were smutty.
It can have an enormous effect because big budget movies can have big budget perks, and small budget movies have no perks, but what is the driving force, of course, is the script, and your part in it.
I'm not a big country guy even though I'm from Nashville. I like some songs, but I wouldn't turn on a country radio station or anything.
'True School' is one great big reminder. It's a reminder to everybody in that middle school bracket that was in school when playing hard to get was out.
Friendship is an arrangement by which we undertake to exchange small favors for big ones.
When you're in front of the camera, for a small budget or a big budget movie, there's no difference.
I went to NYU drama school, so I was a very serious actress. I used to do monologues with a Southern accent, and I was really into drama and drama school. And then, in my last year of drama school, I did a comedy show, and the show became a big hit on campus.
I grew up mostly with classical, big band, and a lot of Irish music - I really didn't start listening to rock and roll until I was maybe sixteen.
Money's not important to me. Movie star acknowledgement is not important to me. I don't want to be a big studio actress. I don't want to be in the limelight.
I never thought about what I would write. I just come from such a big family of storytellers.
I come from a big family of storytellers and, growing up, I liked hearing about the years before I was born.
Vision 2030 is about a lot of big opportunities, so Aramco is one of them, Neom another opportunity.
Nobody messes with China, nobody messes with the United States, or with Europe, because these are really big entities with a lot of clout and a lot of economic power. They have a place at the table.
I'm always working on a few different stories at once, so there's always some really big coffee table book I'm carrying around.
If a person wants to make it big, they can, and they will! The place that they come from doesn't matter, whether small town or big.
We should distinguish carefully skepticism about Big Government from contempt for all government.
I'm really big into yoga, so I go On Demand and look up workouts. I'm all about it.
I've been on big tours ever since I started, but you can't just go out there and headline, you have to do it right.
I auditioned for 'Jake in Progress,' and I was nervous because I had a big crush on John Stamos. I was totally thrown off and couldn't remember my lines.
When I was doing theater for all those years in New York, I did a lot of classical theater, wearing big corsets and big dresses and doing dialects. It's interesting that once I moved to TV, I'm playing these scrappy, contemporary toughies.
And anyway, modeling wasn't for me. I'm too short. I've got a big butt. It wasn't going to happen.
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