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My father was an engineer working for a textile company that had several factories scattered in rural towns in the southern part of Japan.

I commuted to the prestigious Hibiya High School from my uncle's home in Tokyo. During the high school years, I developed an interest in chemistry, so upon graduation, I chose to take an entrance examination for the Department of Chemistry of the University of Kyoto, the old capital of Japan.

I became fascinated by the then-blossoming science of molecular biology when, in my senior year, I happened to read the papers by Francois Jacob and Jacques Monod on the operon theory.

I decided to pursue graduate study in molecular biology and was accepted by Professor Itaru Watanabe's laboratory at the Institute for Virus Research at the University of Kyoto, one of a few laboratories in Japan where U.S.-trained molecular biologists were actively engaged in research.

After I arrived in Basel, I initially attempted to continue the project of my days in Dulbecco's laboratory, namely, the transcriptional control of the simian virus 40 genes.

Immunologists agreed that an individual vertebrate synthesizes many millions of structurally different forms of antibody molecules even before it encounters an antigen.

In the early Seventies, the technology for purifying a specific eukaryotic mRNA was just becoming available.

Although we often discussed the idea of research on the nature of antigen recognition by T cells in the laboratory in the late Seventies while I was still in Basel, the real work did not start until the early Eighties in my new laboratory at M.I.T.

My scientific career has developed on three continents: Asia, Europe and North America.

In 1981, after ten years in Basel, I returned to the United States to continue my research on the immune system at the Center for Cancer Research of the Massachusetts Institute of Technology where Director Salvador E. Luria provided me with an excellent laboratory.

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