Top 10 David Andrew Sinclair Quotes

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I was criticized for saying that Pfizer doesn't know how to make a molecule right.

Well, we can study aging in people, but of course those studies take decades. So what we try to do is we use simpler organisms to try and understand the basic mechanisms and so in my laboratory, for example, we use things like simple baker's yeast that we use to make bread.

We used to think that aging was a lot like, as if we were cars made fresh and youthful and then we've entered this breakdown in diet. What we didn't realize until recently is that we're much more complex than a car. We fix ourselves if we're broken.

So aging is really just the way we deteriorate over time. Lifespan on the other hand is how long we live. We typically refer to that as longevity.

The way to make a worm live longer is probably quite different from making a human live longer.

Well, originally we found resveratrol just in a test tube, looking for molecules that would turn on this enzyme, this protein that seems to defend against diseases in aging.

The mice that had the resveratrol in their diet were still obese, but they were seemingly or relatively immune to the effects of the obesity. So their arteries were clear, their liver was nice and thin. Their bones were stronger. They could run further.

So what we're all hoping to do, us researchers, is to develop ways to not really just extend lifespan but to keep people healthier for longer. We may just have a greater impact than a single drug because these drugs could potentially treat one disease but prevent 20 others.

A lot of scientists are hesitant to get involved with industry. It's seen as, you know, getting in bed with the devil, actually. But I found that doing this has been really the only way and one of the best ways I know to take a finding from the bench side to people.

We once thought of cancer as an incurable disease; then we started treating it.

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