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My brother Joseph, who is 14 years older than me, was already on his national military compulsory service when I was 4 years old, the age from which I remember myself.

I grew up in Haifa and enjoyed the wonderful beaches and Mount Carmel that rolls into the Mediterranean Sea. From my early days at home, I remember a strong encouragement to study.

My father left me with his love of Jewish studies and cultural life. To this very day, along with several physicians and scientist colleagues, I take regular periodical lessons taught by a Rabbinical scholar on how the Jewish law views moral and ethical problems related to modern medicine and science.

Towards the end of the military service, I had to make what I assume has been the most important decision in my career: to start a residency in clinical medicine, in surgery, which was my favorite choice, or to enroll into graduate school and start a career in scientific research. It was clear to me that I was heading for graduate school.

The problem of different sensitivities of distinct protein groups to lysosomal inhibitors has remained unsolved and may have served as an important trigger in the future quest for a non-lysosomal proteolytic system that may be involved in at least certain aspects of intracellular protein degradation.

Reticulocytes are terminally differentiating red blood cells that do not contain lysosome. Therefore, it was postulated that the degradation of hemoglobin in these cells is mediated by a non-lysosomal machinery.

The development of methods to monitor protein dynamics in cells together with the discovery of specific and general lysosomal inhibitors have resulted in the identification of different classes of cellular proteins, long- and short-lived, and the findings of the differential effects of the inhibitors on these groups.

The evolvement of proteolysis as a centrally important regulatory mechanism is a remarkable example for the development of a novel biological concept and the accompanying battles to change paradigms.

Biochemistry is the science of life. All our life processes - walking, talking, moving, feeding - are essentially chemical reactions. So biochemistry is actually the chemistry of life, and it's supremely interesting.

To develop drugs for people, we basically dismantle the system. In the lab, we look at things the size of a cell or two. We dismantle life into very small models.

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