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I was sure I was going to be a doctor of global health or tropical medicine in some underdeveloped country.

We need to ask whether, in the long term, some individuals with a history of psychosis may do better off medication.

My philosophy is really based on humility. I don't think we know enough to fix either diagnostics or therapeutics. The future of psychiatry is clinical neuroscience, based on a much deeper understanding of the brain.

When we talk about the brain, it is anything but unidimensional or simplistic or reductionistic.

The good-news stories in medicine are early detection, early intervention.

In the 1830s, Dorothea Dix revolutionized the care of people with mental illness by taking them out of jails and caring for them in asylums, later known as state hospitals.

Sometimes, patients with serious mental illness, just as with other serious medical illnesses, require hospitalization. In the absence of available public or private hospital beds, there are few options.

As a scientist leading a funding agency for autism research, I think of autism as a neurodevelopmental disorder.

What do we know about autism in 2013? Autism symptoms generally emerge before age three and usually much earlier, often as language delays or lack of social engagement. Recent research suggests that autism can be detected during the first year of life, even before classic symptoms emerge. Indeed, the symptoms may be a late stage of autism.

What causes autism? As far as we know in 2013, there is no single gene or single environmental factor that accounts for the more than 1 million Americans with ASDs.

A National Database on Autism Research is fostering sharing of data and collaborations. Scientists are also making great strides at the interface of biology and engineering with new technologies that are laying the groundwork for future advances.

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