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As a brand new graduate student starting in October 1956, my supervisor Michail Fischberg, a lecturer in the Department of Zoology at Oxford, suggested that I should try to make somatic cell nuclear transplantation work in the South African frog Xenopus laevis.

There is no doubt that I was blessed with a considerable amount of luck.

Within one year of starting work, I had found that the nucleus of an endoderm cell from an advanced tadpole was able to yield some normal development up to the nuclear transplant tadpole stage.

I wondered whether the nuclear transfer techniques could be used to introduce purified macro-molecules into an egg, and hence into embryonic cells.

For my part, I have worked all my life with eggs and embryos of frogs. Compared to other small animals, these have figured prominently in the world of literature.

Shinya Yamanaka's work has involved mice and human cells, and advances the prospect of providing new cells or body parts for patients.

I myself have been a major beneficiary of the view that no animal will more repay treatment that is kind and fair.

The earliest example known to me of replaced body parts is exemplified by a Mayan skull dating back to 1400 BC. In this skull, false teeth made of stone had been implanted.

I get into lab early and leave a bit early, too. So I like to have an hour or two before everybody comes in.

I left my frogs, which I had grown, with my supervisor, who had moved to Geneva, and he and a technician grew them up. So by 1962, they were adults, and one could publish a paper to say that these animals, derived from nuclear transfer, really were absolutely normal. So it took a little time to get through.

Once the principle is there, that cells have the same genes, my own personal belief is that we will, in the end, understand everything about how cells actually work.

I think that I cannot immediately see the route by which we should really understand memory and the workings of the brain.

I have this rather amazing report which, roughly speaking, says I was the worst student the biology master had ever taught.

There's a danger of some of the best people saying, 'I don't want a career in science.'

If you explain to a patient what can be done and what might be the downsides, let the patient choose; don't have ethicists, priests, or doctors say you may or may not have replacement cells.

The work I was involved in had no obvious therapeutic benefit. It was purely of scientific interest. I hope the country will continue to support basic research even though it may have no obvious practical value.

It is particularly pleasing to see how purely basic research, originally aimed at testing the genetic identity of different cell types in the body, has turned out to have clear human health prospects.

I must have been born with a strong attraction toward, and possibly even an aptitude for, doing things on a small scale.

I remember that, at an early age, I spent many months making a three-masted sailing boat with rigging in a half-walnut shell.

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