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I was born in the shadow of World War II, on December 18, 1939, on the South Shore of Long Island, a product of the early -wentieth-century emigration of Eastern European Jewry to New York City and its environs.

The public schools I attended were dominated by athletics and rarely inspiring intellectually, but I enjoyed a small circle of interesting friends despite my ineptitude at team sports and my preference for reading.

Following graduation from Amherst, a Woodrow Wilson Fellowship enabled me to test the depth of my interest in literary scholarship by beginning graduate studies at Harvard University.

In preparation for a career in academic medicine, I worked as a medical house officer at Columbia-Presbyterian Hospital from 1966 to 1968 and then joined Ira Pastan's laboratory at the National Institutes of Health as a Clinical Associate.

As an undergraduate at Amherst College, I was devoted to Dickensian novels and antiestablishment journalism while marginally fulfilling premedical requirements.

Just after graduation in 1966, like many of my contemporaries, I applied for research training at the National Institutes of Health. Perhaps because his wife was a poet, Ira Pastan agreed to take me into his laboratory, despite my lack of scientific credentials.

A major feature of life at the NIH in late 1960s was the extraordinary offering of evening courses for physicians attempting to become scientists as they neared thirty.

From some dilatory reading in the early 1960s, I knew enough about viruses and their association with tumors in animals to understand that they might provide a relatively simple entry into a problem as complex as cancer.

I begin with the premise that behavior is an incredibly important element in medicine. People's habits, their willingness to quit smoking, their willingness to take steps to avoid transmission of HIV, are all behavioral questions.

When I read about genetics, I see breakthroughs every day. And while I'm trying to learn more about behavioral science, I must say that I don't feel I get tremendous intellectual stimulation from most of the things I read.

I saw my friends in medical school seeming to be more engaged with the real world. That provoked a sort of jealousy, and I decided to go to medical school after all.

When I was the NIH director, I often expressed envy of institute directors: they had the money and ran the scientific programmes.

Cancer is a collection of many diseases with common principles, and each disease will have to be understood and more effectively controlled on its own terms.

The NCI scientific programme leaders meet regularly to ensure that we are not ignoring highly original proposals and that we are not creating an unbalanced grant portfolio.

All basic scientists who look to the NCI for funding should know that I will tolerate no retreat on the study of model systems and the pursuit of fundamental biological principles.

I'm used to being surrounded by really smart 22-year-old students who have no problem saying that something I suggested is not a very good idea.

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