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Both of my parents were first-generation Americans, the children of Jews who left Eastern Europe around the turn of the century.

It was my father who - after, at age 15, I had attempted unsuccessfully to drive the family car using a 'borrowed' key and knocked down a wall of the garage - convinced me over the telephone not to run away from home and who then came home from work not to punish me but rather to console and comfort me.

My mother has been a wonderful model for the professional woman - a loving mother dedicated to both her family and her work. She inspired me, made me proud, and developed in me an enormous respect for women in general.

My scientific pursuits have led to many opportunities and responsibilities beyond those of simply doing research. For example, as a beginning graduate student, it never occurred to me that the life of a scientist could involve so much travel, something that I have always loved.

The number of cells in our bodies is defined by an equilibrium of opposing forces: mitosis adds cells, while programmed cell death removes them. Just as too much cell division can lead to a pathological increase in cell number, so can too little cell death.

Because of the relationship between programmed cell death and human disease, the identification of the genes and proteins that function in the process of programmed cell death has provided new targets for possible intervention in a broad diversity of disorders.

Time and time again, truly basic studies of simple experimental organisms have proved directly relevant to human biology and human disease. An investment in such basic studies is an effective investment indeed.

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