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There was little in my early life to indicate that an interest in biology would become the passion of my academic career. In fact, there was little to suggest I would have an academic career.

I was born in Vienna on November 7, 1929, eleven years after the multiethnic Austro-Hungarian Empire fell apart following its defeat in World War I.

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My parents genuinely loved Vienna, and in later years I learned from them why the city exerted a powerful hold on them and other Jews. My parents loved the dialect of Vienna, its cultural sophistication, and artistic values.

My parents were not born in Vienna, but they had spent much of their lives there, having each come to the city at the beginning of World War I when they were still very young.

In the 1950s and early 1960s, psychoanalysis swept through the intellectual community, and it was the dominant mode of thinking about the mind. People felt that this was a completely new set of insights into human motivation, and that its...

The problem of psychoanalysis is not the body of theory that Freud left behind, but the fact that it never became a medical science. It never tried to test its ideas.

Long-term memory involves enduring changes that result from the growth of new synaptic connections.

You could double the number of synaptic connections in a very simple neurocircuit as a result of experience and learning. The reason for that was that long-term memory alters the expression of genes in nerve cells, which is the cause...

I was interested in the nature of human mental processes, which is what got me interested in psychoanalysis. And it became clear to me after a while that mental processes come from the brain, and in order to understand them,...

I have a philosophy that has guided me throughout all of my scientific career, and that is, I think of myself as a fairly thoughtful person. I don't go into projects impetuously, and I try to select important problems.

I like problems at the borders of disciplines. One of the reasons that neurobiology of learning and memory appeal to me so much was that I liked the idea of bringing biology and psychology together.

I was reluctant to be critical of the United States because I thought the United States could do no wrong; that the government could not lie to its people.

In order to produce learned fear, you take a neutral stimulus like a tone, and you pair it with an electrical shock. Tone, shock. Tone, shock. So the animal learns that the tone is bad news. But you can also...

You learn emotional experiences as much as you learn cognitive experiences, except that they are more unconscious. Sometimes one represses the cognitive component of it, but it's often more difficult to repress the emotional component.

Early in my career, I was disappointed that psychoanalysis was not becoming more empirical, was not becoming more scientific. It was primarily concerned with individual patients. It wasn't trying to collect data from large groups of people who have been...

What the Ellison Foundation and I are hoping to encourage is a more holistic approach to psychiatry, in which psychotherapy is put on as rigorous a level as psychopharmacology.

Rather than studying the most complex form of memory in a very complicated animal, we had to take the most simple form - an implicit form of memory - in a very simple animal. So I began to look around...

Nerve cells communicate with one another at specialized points called synapses. And these synapses are plastic - they can be modified by learning.

I went to medical school after having decided to do so somewhere between my junior and senior year at Harvard - very late. I initially wanted to be an intellectual historian.

I found working in the lab is so completely different than reading a textbook about it. You know, you're planning strategies; you're working with your own hands. There's essential satisfaction in running experiments.

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