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Flying back from New York, the flight attendant said 'God, I wished you were here yesterday, we had a stroke on the plane. I said, if I have a stroke on a plane, I hope the pretend doctor isn't the one on the plane. I want a real doctor.

There's really no point in having children if you're not going to be home enough to father them.

My family had all kinds of complications in relationships. I would like to meet the person who did not. Since when is being absolutely perfect what being a human is? What do we gain from that?

David Fincher is a longtime friend. As a director, my wife had worked with him as a makeup artist when he would do Madonna videos years before, and his child and my oldest child were in preschool together, so we're kind of dad-friends through that, too.

So I was hugely thrilled that my first scene ever on camera was with Hal Holbrook.

I'm the youngest of five kids, and I wanted attention. And in Santa Barbara, there was lots of theater going on, so for that area, it was a little bit like playing Little League baseball. There were dance classes, theater classes, and I just loved it.

I did tons of theater in school, and then when I was 16 and got my driver's license, I started driving to Los Angeles, along with my friend Eric Stoltz, who was a year ahead of me and was doing the same thing. So we had the same manager, and we started auditioning for things and doing commercials when we were 16.

Knock wood, but I started acting professionally when I was 16, and I've always been able to support myself since then.

'ER' was so huge that whatever I did coming back to television, I'd have to feel as strongly about.

I love being a part of something that is grassroots, and you can see the actual changes, the effect of what people do.

I didn't start jogging or running until I was 37 years old. It was something that really helped me change my life.

Why is there such vanity about hair? I make a point to bathe. I worry about boogers in my nose, and I ask the makeup artist to cover up my pimples, but beyond that, I try not to be too vain.

People relate to things that feel real to them. All the good, happy, over-sexed and moneyed endings on TV are not the way most of us feel in our lives. The success of 'E.R.,' I think, is not relying on overly sentimental stories that are solved where people's lives wrap up nicely with happy endings.

I was always enjoying the moment. Acting, writing, looking for roles and getting involved with people and trying to create something that would be entertaining to people. With 'E.R.,' we were all very lucky to get this combination of people together in the right story in the right way to take it to the level it has reached.

There are definitely roles within this industry that are industry-related, but to be a good actor, you really have to want to act first. At the same time, my goal was never to go to Hollywood to make movies. I think if you come here with that attitude, then you've missed a few steps.

It's difficult to keep that perspective, I think, as a parent: to know your boundaries as to what's good parenting or just projecting your own expectations on your kids. That's the hardest.

You know, you never say never because before I did 'ER,' I always said 'I'll never do a TV series,' so that's what I said.

I just spent a lot of time on 'ER' for that eight years. I also started working when I was 16, so by the time I left 'ER,' I was 40 years old, I had this incredible experience, my wife had this great company, we had four kids, it was like, 'Let's go to New York and live for a while and make that the priority.'

I had this thing about hanging out in dark theaters. My family thought I grew out of a rock.

I was spoiled by theater, where there is no editor.

To think one film makes a career is ridiculous. It's important to keep perspective and do things other than for money.

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